Can zopiclone cause the health problem
The most common is the sensation
of "bitter taste in the mouth" referred by patients. The following
adverse effects have been reported: General: headache, muscle weakness. Central
nervous system: residual daytime sleepiness, decreased alertness, vertigo,
anterograde amnesia, confusion, asthenia and, exceptionally, ataxia, diplopia,
libido modification.
Dependency and rebound of insomnia after
discontinuation of treatment. Gastrointestinal: nonspecific discomfort. In some
patients, often elderly, paradoxical reactions consisting of irritability,
vertigo, aggressiveness, agitation, hallucinations and depersonalization may
occur (see Warnings). Skin reactions and pruritus have been described.
Warnings
The development of drug
dependence cannot be excluded. Various factors seem to favor its production:
duration of treatment, dose, association with other medications (anxiolytics,
antipsychotics, hypnotics, etc.) and a history of other drug dependencies,
including alcohol. It is not advisable to extend the treatment beyond 4 weeks,
a progressive decrease in the dose is beneficial.
Amnesia
Anterograde amnesia is possible,
particularly when sleep is interrupted (waking up early due to an external
event) or there is a delay in going to bed after taking the tablet. To prevent
this eventual phenomenon, zopiclone should be administered at bedtime.
It has been reported in patients undergoing
treatment with non-benzodiazepine hypnotics the appearance of alterations of
thought or behavior. Some of these changes may be characterized by decreased
inhibition (eg aggressiveness, outgoing behavior) similar to those evoked by
alcohol consumption and other CNS depressants (see Drug Interactions).
Behavioural disturbances
Other reported behavioral
disturbances included bizarre behavior, agitation, hallucinations and
depersonalization. Because some of the adverse effects of these drugs are dose
dependent, it is important to remember that the daily dose should not exceed
the recommended maximum and that it should always be the minimum necessary to
achieve the desired therapeutic effects, especially in the elderly.
In patients with primary
depression treated with both benzodiazepine and non-benzodiazepine hypnotics,
cases of worsening symptoms have been reported, even leading to suicidal
ideation. Rarely can it be determined with precision whether any of the
aforementioned behavioral alterations were caused by the drug, spontaneously,
or as a result of an underlying psychiatric or medical illness.
Best time to take this medicine
Due to the rapid onset of its
pharmacological action after oral administration, this medication should be
taken just before bedtime. Patients should be advised not to perform tasks that
require total attention and / or precise motor coordination, such as the
operation of dangerous machinery or driving vehicles, after taking this
medication.
Major Side Effects
Tolerance: The therapeutic effect of benzodiazepines and related
drugs may decrease with repeated use for several weeks. Even though it has not
yet been reported with zopiclone, the tolerance phenomenon must be taken into
account, strictly respecting the maximum treatment time including the
progressive discontinuation period. After four weeks of treatment, the specialist
must reassess the need to continue or not the administration of the hypnotic.
Dependence: In patients treated for a long time and, especially
with doses higher than those recommended, signs and symptoms compatible with
withdrawal symptoms have been described.
It is
recommended to progressively withdraw treatment with zopiclone in order to
minimize the risk of withdrawal syndrome and alert the patient to the
possibility of it, notifying the doctor if manifestations such as headache,
insomnia, muscle aches, anxiety, agitation occur , confusion, irritation and in
severe cases seizures.Source: Can zopiclone cause the health problem@zopiclone247
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